KINARM Labs are the most advanced and flexible robotic platforms for undertaking sensory, motor and cognitive research. After 10 successful years, KINARM Labs are trusted research tools giving our customers confidence in their research results.
KINARM was first designed as a tool to study upper-limb voluntary motor control and specifically the difficulty of quantifying and manipulating the mechanics of multi-joint motion in the NHP while simultaneously recording neural function. Scott extended the design to a human-sized version providing further insight on motor learning (e.g. Singh and Scott, 2003). He then modified the system to a make it more clinically-friendly and include two robots, one for each limb (Nozaki et al., 2006).
This technology has been influential in uncovering many novel aspects of voluntary motor control. Scott lab has had over a dozen Nature series publications (Scott et al., 2001; Gribble and Scott, 2002; Singh and Scott, 2003; Kurtzer et al., 2005; Nozaki et al., 2006; Pruszynski et al., 2011). Others such as Hatsopoulos Lab (Rubino et al., 2006), Carmena Lab (Gangully et al., 2011) and Bastian Lab (Bhanpuri, et al., 2014) have had similar success. Scott is currently focused on optimal feedback control (OFC) as a theory of voluntary control (Todorov and Jordan, 2002). He has been one of the leaders in the field articulating the importance and impact of this new theory, particularly its implications on the neural basis of control (Scott, 2016; Scott, 2004).
KINARM Labs are highly flexible platforms that enable researchers to develop and implement their own custom experimental paradigm to address leading questions in neuroscience, such as:
• Learning in altered visual and mechanical environments
• Solving complex cognitive problems
• Perceptual aspects of proprioception and body image
• Dissociation of visual and mechanical worlds (e.g. visuomotor rotation task)
• Force Channel (KINARM End-Point only)
• Multiple simultaneous loads (e.g. force-field + perturbation)
• Complex visual stimuli, static and dynamic
KINARM labs provide a robust experimental platform for quantifying impairments from acquired brain injury and disease.
Using advanced technologies, such as robotics, BKIN has created the most advanced labs for measuring human behavior – a method we call behaviorography™ – that will provide objective and quantitative measures of brain function overcoming the limitations of existing clinical tests.The robotic assessment device combined with an augmented reality system creates a virtual environment where subjects perform tasks, such as directing a hand to a target, or interacting with an object in the environment. A person either sits in a chair with robotic arms affixed (KINARM Exoskeleton Lab) or grasps on to two robotic manipulandums (KINARM End-Point Lab).
During a KINARM Standard Test task, the device precisely tracks, measures and records every arm movement providing support or resistance as needed. Using BKIN’s proprietary software Dexterit-E, a detailed report of measurements is produced and compared to age-matched controls. Other technologies such as gaze-tracking and force plates are also available to capture more behavioral information.
KINARM Labs enable the development and validation of patient-specific therapies for persons suffering from brain injury and disease.
KINARM Labs allow clinical researchers to:
Identify subject-specific behavioral measures that uniquely characterize the subject’s neurological deficit
Design new patient-centered therapies to address the patient-specific impairment of the brain injury or disease
Translate treatments for brain injury from lab to clinic
Science stands behind every test
Identify subjects for research protocols based on their deficit profile
Collect objective data on the subject’s response to therapies
Clinical Research on Brain Health
• Quantify motor, sensory and cognitive deficits associated with a neurological disorder
• Identify novel biomarkers for clinical assessment
• Quantify patient performance for novel rehabilitation strategies
All KINARM Labs rely on the common principle that the upper limb can give a wealth of information about the function of the brain. But how do we know this? Over the last 40 years, our understanding of how the brain supports sensory, motor, and cognitive function has substantially increased due to availability of advanced technologies, such as robotics. Behavioural studies on humans have identified how we use sensory input to the brain to perceive the world around us, make decisions, and guide our highly skilled and flexible motor actions. Many of these studies have used the upper limb as a model to test their hypotheses, for example:
- sensory and motor systems work together to permit us to move and interact in the environment and create our perception of the world;
- a given function is supported by a highly distributed network in the brain; and
- the ability to perform sensory, motor, and cognitive functions requires substantial learning so that brain processing is highly plastic and altered by experience. (Scott et al, 2011).
Many publications are available that elucidate these three key findings.
Given the breadth of sensory and motor processes now studied, it is well-recognized that numerous neurological diseases and injuries will disrupt the complex network that moves the upper limb and that such disruption can now be quantified with the assistance of robotics. With KINARM Labs, the possibility now exists to identify sensitive biomarkers of healthy performance against which impairments can be identified.
For example, a motor function such as point-to-point movement evaluation is currently evaluated by the clinician asking the patient to touch his finger and their nose repeatedly and scored 0, 1 or 2. In the KINARM lab this motor function is evaluated by first quantifying the behaviour of a healthy subject with kinematic variables such as reaction time, speed differences between limbs and direction errors, and then assembling a large normative database of age-matched controls. The impaired subject performs the same task and their performance is then compared. The parameter is identified if performance is beyond the 5-95 confidence interval (Coderre, et al., 2010). This paradigm has been repeated in numerous behavioural tasks by Scott and others, and has enabled BKIN to develop KINARM Standard Tests.